A History of Simple Indole Extraction and Isolation Techniques

I have found the lack of knowledge from academic journals on the net regarding this subject somewhat disappointing, so to remedy this, I have decided to source some of the methods sections from a few journals in the past that dealt with this matter. If any of the authors or publishers wish any of this material to be removed, please contact me at [email protected] and I will be happy to remove the offending information. Likewise, if you have any questions regarding these procedures, please feel free to contact me. 

 

Mucunapruriens.htm S. Ghosal, S. Singh and S.K. Bhattacharya, "Alkaloids of Mucuna pruriens – Chemistry and pharmacology", Planta Medica 19, 279 (1971).

Horsfiline.htm A. Jossang, P. Jossang, H.A. Hadi, T. Sevenet, B. Bodo, "Horsfiline, An Oxindole Alkaloid from Horsfieldia superba", J. Org. Chem. 56, 6527 (1991).

 

Acaciarigidula.htm B.A. Clement, C.M. Goff, T.D.A. Forbes, "Toxic amines and alkaloids from Acacia rigidula", Phytochem. 49(5), 1377 (1998).

Acerdictpiptmimosa.htm I.J. Pachter, D.E. Zacharias, O. Ribeiro, "Indole Alkaloids of Acer saccharinum (the Silver Maple), Dictyloma incanescens, Piptadenia columbrina, and Mimosa hostilis", J. Org. Chem. 24, 1285 (1959).

 

General useful information in alkaloid extractions, plus a couple links to extraction procedures on the net:

 

Physical properties of the naturally occurring tryptamines on Erowid – useful information when extraction procedures need to be developed:

http://www.erowid.org/chemicals/dmt/dmt_chemistry.shtml (DMT)

http://www.erowid.org/chemicals/bufotenin/bufotenin_chemistry.shtml (Bufotenine)

http://www.erowid.org/chemicals/ibogaine/ibogaine_chemistry.shtml (Ibogaine)

 

The following links explain some of the equipment and methods used in alkaloid extraction:

Reagderiv.htm - Use of Reagents and Derivatives – Alkaloid derivatives for identification, Mixed Melting Points etc…

Aparatii Used in Extraction Procedures (Link not established yet!) - Includes Soxhlet and others

Chromatography.htm - Chromatography Theory (Link not established yet!) – TLC, HPLC, Column, Co-Chromatography

 

For a good review of the basic theory of extraction, check out these links:

http://dmt.lycaeum.org/extract/yoda.html

http://www.lycaeum.org/drugs/other/extraction/

This page is still under construction…